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Filtered Search Results
Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000695532 HYDROQUININE 25G
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NANOPARTZ INC C11-10-MS-DIH-50-1
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NC3717122 C11-10-MS-DIH-50-1
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Chem-Impex International, Inc. CHEM IMPEX INTL INC
NC4029543 7-AZABENZOTRIAZOL-1 25G
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Sigma Aldrich Fine Chemicals Biosciences Quinine suitable for fluorescence, anhydrous, >=98.0% (dried material, NT) | 130-95-0 | MFCD00198096 | 25G
Quinine suitable for fluorescence, anhydrous, >=98.0% (dried material, NT) | Purity: >=98.0% (dried material, NT) | Mol Wt: 324.42 | 130-95-0 | MFCD00198096 | 25G
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Apexbio Technology LLC Palifosfamide 31645-39-3 200mg
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Palifosfamide (CAS 31645-39-3) is the active metabolite derivative of ifosfamide (IFA) an alkylating agent exhibiting cytotoxic effects through cross-linking DNA strands thereby interfering with replication and transcription Palifosfamide lysine demonstrates anticancer activity against pediatric sarcoma cell lines including osteosarcoma models such as SAOS-2 (IC50 2 25 6 75 M) and decreased sensitivity in OS222 (IC50 31 5 M) In murine xenograft experiments (MX-1 tumors) palifosfamide treatment at 100 mg/kg showed substantial tumor growth inhibition ( 80%) and partial complete response rates ( 17%) highlighting its applicability in preclinical oncology research
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AURUM PHARMATECH INC TERT-BUTYL N-METHYL-N-CARBA 1G
NC3454432 TERT-BUTYL N-METHYL-N-CARBA 1G
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000694863 6-BROMOISOQUINOLINE 500G
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Apexbio Technology LLC Fluvastatin Sodium 93957-55-2 200mg
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Fluvastatin Sodium (CAS 93957-55-2) is an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase the rate-limiting enzyme in cholesterol biosynthesis By blocking HMG-CoA reductase activity fluvastatin reduces serum total cholesterol LDL-cholesterol and apolipoprotein B while increasing HDL-cholesterol and apolipoprotein A-I levels In research settings fluvastatin exhibits anti-atherosclerotic anti-thrombotic and antioxidant properties Studies have shown fluvastatin decreases platelet aggregation dose-dependently in vitro reducing platelet aggregation by approximately 10-15% at clinical doses (40 mg/day) Additionally fluvastatin inhibits inflammatory angiogenesis and NO production suggesting potential applications in inflammatory and cardiovascular research
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eMolecules 1255942-06-3 | DBCO-amine | Broadpharm | MFCD22380759 | 276.339 | C18H16N2O | 98.000 | NCCC(=O)N1Cc2ccccc2C#Cc2ccccc12 | 250mg | 254745543
DBCO-amine | Broadpharm | 1255942-06-3 | MFCD22380759 | 276.339 | C18H16N2O | 98.000 | NCCC(=O)N1Cc2ccccc2C#Cc2ccccc12 | 250mg | 254745543
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eMolecules 13482-22-9 | 4-hydroxycyclohexan-1-one | Pharmablock | MFCD02093817 | 114.144 | C6H10O2 | 97.000 | OC1CCC(=O)CC1 | 10g | 551220082
4-hydroxycyclohexan-1-one | Pharmablock | 13482-22-9 | MFCD02093817 | 114.144 | C6H10O2 | 97.000 | OC1CCC(=O)CC1 | 10g | 551220082
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eMolecules 59483-84-0 | Bis(perfluorophenyl) carbonate | ChemScene | MFCD00368353 | 394.124 | C13F10O3 | 98.000 | Fc1c(F)c(F)c(OC(=O)Oc2c(F)c(F)c(F)c(F)c2F)c(F)c1F | 10g | 711935695
Bis(perfluorophenyl) carbonate | ChemScene | 59483-84-0 | MFCD00368353 | 394.124 | C13F10O3 | 98.000 | Fc1c(F)c(F)c(OC(=O)Oc2c(F)c(F)c(F)c(F)c2F)c(F)c1F | 10g | 711935695
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Apexbio Technology LLC Ciprofibrate 52214-84-3 200mg
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Ciprofibrate is a selective agonist targeting peroxisome proliferator-activated receptor alpha (PPAR ) a nuclear receptor involved in regulating lipid metabolism and energy homeostasis Its activation promotes gene expression linked to fatty acid oxidation triglyceride reduction and cholesterol metabolism Ciprofibrate is frequently applied as a molecular tool in biomedical research to investigate mechanisms underlying dyslipidemia atherosclerosis and metabolic-related disorders Additionally due to its receptor-specific mode of action it serves as a standard experimental reference in in vitro assays and animal models assessing lipid-lowering therapeutic strategies and PPAR -dependent signaling pathways
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Apexbio Technology LLC Matrine(Synonyms: Sophocarpidine, Matridin, (-)-Matrine, α-Matrine, (−)-α-Matrine, L-Matrine, Kushenin), 200mg, CAS: 519-02-8.
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Matrine (CAS 519-02-8) is an alkaloid derived from plants in the Sophora genus with demonstrated anticancer and anti-inflammatory activities It functions in part through agonism of kappa-opioid and possibly other receptors Matrine inhibits the MNK45 gastric cancer cell line proliferation (IC50 540 g/ml MTT assay) by modifying protein expression profiles (e g NF- B XIAP CIAP p-ERK) In vitro matrine induces apoptosis in NSCLC cells through ROS generation caspase activation and p38 pathway modulation Animal studies suggest therapeutic roles in cardiac injury and sepsis-related lung inflammation
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Medchemexpress LLC VK-II-86 | 955371-84-3 | 93.3% | 420.50 | 500 MG
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VK-II-86 is a Carvedilol analogue that lacks antagonist activity at β-adrenoceptors in hypokalaemia. This compound effectively prevents hypokalaemia-induced ventricular arrhythmia through its multi-channel effects, counteracting all hypokalaemia-induced changes in ion channel activity and oxidative stress. For research use only.
- Carvedilol analogue
- Lacks antagonist activity at β-adrenoceptors
- Prevents hypokalaemia-induced ventricular arrhythmia
- Exhibits multi-channel effects
- Counters hypokalaemia-induced changes in ion channel activity
- Counters hypokalaemia-induced oxidative stress
- Markedly reduces non-sustained and sustained ventricular tachyarrhythmias in a hypokalaemic murine whole-heart model
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Medchemexpress LLC Amifostine (trihydrate) | 112901-68-5 | 100.0% | 200 MG
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Amifostine trihydrate is a broad-spectrum cytoprotective agent and radioprotector. It selectively protects normal tissues from damage caused by radiation and chemotherapy. It acts as a potent hypoxia-inducible factor-α1 (HIF-α1) and p53 inducer, protecting cells by scavenging oxygen-derived free radicals. It also reduces renal toxicity and exhibits antiangiogenic action.
- Broad-spectrum cytoprotective agent
- Radioprotector
- Selectively protects normal tissues from radiation and chemotherapy damage
- Potent HIF-α1 and p53 inducer
- Scavenges oxygen-derived free radicals
- Reduces renal toxicity
- Exhibits antiangiogenic action
- Protects against tert-Butyl hydroperoxide (TBHP)-induced cell damage
- Reduces H9c2 cell apoptosis
- Provides protection against myocardial ischemia/reperfusion injury
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